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目的了解烟台市区耐药结核病的流行现状及特点,为制定和完善防控措施及指导临床用药提供依据。方法按照WHO和国际防痨和肺部疾病联合会(IUATLD)结核病耐药监测指南,收集2015年1~12月烟台肺科医院门诊及住院440例肺结核患者痰标本,135例分离出结核分枝杆菌,采用比例法对利福平(R)、异烟肼(H)、链霉素(S)、乙胺丁醇(E)等4种药物进行药物敏感性试验。采用SPSS 18.0进行统计学分析,率的比较采用卡方检验,以P<0.05为差异有统计学意义。结果 135株结核分枝杆菌分离菌株中,总耐药率21.48%,初治耐药率18.97%,复治耐药率36.84%。结论烟台市区结核分枝杆菌总耐药率、初始耐药率、耐多药率均低于2010年全国结核流行病学调查结果,也低于山东省部分地市报告的疫情水平。
Objective To understand the epidemic situation and characteristics of drug-resistant tuberculosis in Yantai city and provide basis for establishing and improving prevention and control measures and guiding clinical drug use. Methods According to the guidelines of WHO and International Union Against Tuberculosis and Tuberculosis (IUATLD), sputum samples from 440 outpatients and hospitalized patients in Yantai Pulmonary Hospital between January and December 2015 were collected and 135 cases were separated from tuberculosis branches Bacilli, the drug sensitivity test was conducted on four drugs, rifampicin (R), isoniazid (H), streptomycin (S) and ethambutol (E) SPSS 18.0 was used for statistical analysis, the rate of comparison using the chi-square test to P <0.05 was considered statistically significant. Results Among 135 isolates of Mycobacterium tuberculosis, the total drug resistance rate was 21.48%, the initial drug resistance rate was 18.97% and the re-treatment rate was 36.84%. Conclusion The total drug resistance, initial drug resistance and multidrug resistance of Mycobacterium tuberculosis in Yantai were lower than those of the national epidemiological survey of tuberculosis in 2010 and lower than the reported epidemic levels of some cities in Shandong.