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目的探讨糖尿病家族史与高血压对2型糖尿病(T2DM)的发病是否存在交互作用。方法选取现场调查筛出的新发T2DM患者791例为病例组,以同期调查的血糖正常者4 374例为对照组,比较两组糖尿病家族史与高血压的患病率差异,运用相加模型分析糖尿病家族史和高血压在T2DM的发病中是否存在交互作用。结果病例组有糖尿病家族史的比例(χ2=40.13,P<0.001)和高血压患病率(χ2=120.35,P<0.001)均高于对照组。采用多因素非条件Logistic回归模型控制混杂因素后,糖尿病家族史与高血压共同存在对T2DM患病的协同效应指数为1.19,归因交互效应为0.52,归因交互效应百分比为12.2%,纯因子间归因交互效应百分比15.71%。结论糖尿病家族史与高血压对T2DM的发病有正交互作用,两者同时存在可增加罹患T2DM的危险性。
Objective To investigate whether family history of diabetes mellitus and hypertension have an interaction with type 2 diabetes mellitus (T2DM). Methods A total of 791 newly diagnosed T2DM patients screened out by on-site investigation were selected as case group. The prevalence of family history of hypertension and hypertension was compared between 4 374 normal subjects and 4 754 normal subjects. The additive model To analyze the family history of diabetes and hypertension in the pathogenesis of T2DM whether there is interaction. Results The family history of diabetes (χ2 = 40.13, P <0.001) and the prevalence of hypertension (χ2 = 120.35, P <0.001) were higher in the case group than in the control group. After using multivariate non-conditional Logistic regression model to control confounding factors, the synergistic effect index of family history of diabetes with hypertension on T2DM prevalence was 1.19, the attribution interaction effect was 0.52, the attribution interaction effect percentage was 12.2%, the pure factor The percentage of interpersonal interactions was 15.71%. Conclusion The family history of diabetes and hypertension have an orthogonal interaction on the pathogenesis of T2DM. The combination of both can increase the risk of T2DM.