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为了研究两剂重组乙型肝炎(HB)疫苗免疫方案诱导的初次和记忆应答,作者将200名18～39岁健康成人随机分成两组,分别于0、6月接种10μg(Ⅰ组)或20μg(Ⅱ组)酵母重组HB疫苗,并于初次接种后2年加强1次.于初次接种后1、2、3、6、7、24个月、2年后1周及2年后3～4周采血,用放射免疫法检测抗-HBs滴度,滴度≥10mIU/ml定为具有保护作用.结果表明,在接种第2剂疫苗前,Ⅰ组和Ⅱ组分别只有46%和67%的人抗-HBs≥10mIU/ml(P=0.006),而初次接种后3～6月,两组各有74%～78%和80%～87%的人可检出抗体,两组累积血清阳转率均较高且
In order to investigate the primary and memory responses induced by two doses of recombinant hepatitis B vaccine, 200 healthy adults aged 18-39 years were randomly divided into two groups. One group received either 10 μg (group Ⅰ) or 20 μg (Group Ⅱ) recombinant HB vaccine yeast, and in the first 2 years after vaccination to strengthen 1. In the first inoculation after 1,2,3,6,7,24 months, 1 year after 2 years and 3 years after 2 years Weeks of blood collection, radioimmunoassay detection of anti-HBs titer, titer ≥ 10mIU / ml as a protective effect.The results showed that before inoculation of the second vaccine, Ⅰ and Ⅱ group were only 46% and 67% Human anti-HBs ≧ 10 mIU / ml (P = 0.006), and from 3 to 6 months after the initial inoculation, 74% -78% and 80% -87% of the antibodies in both groups were detectable. Turnover rates are high