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目的:观察滇总黄芩黄酮提取物的小鼠急性毒性及对乌头碱诱发大鼠实验性心律失常的影响。方法:①以Bliss法测定滇黄芩总黄酮提取物的急性毒性;②通过测定大鼠心电图研究滇黄芩总黄酮的抗心律失常作用。结果:①滇黄芩总黄酮提取物对小鼠有一定急性毒性,但半数致死量(LD50,4.4388g·kg-1体重)与抗心律失常实验所采用的中剂量(20mg·kg-1体重)的剂量距离较远;②滇黄芩总黄酮提取物能明显增加乌头碱诱发大鼠室早(VP)、室颤(VF)和室性停搏(CA)所需的阈剂量;可剂量依赖性地缩短肾上腺素致麻醉豚鼠心律失常的持续时间。结论:滇黄芩总黄酮提取物对小鼠毒性小,但有明显的抗实验性心律失常作用。
OBJECTIVE: To observe the acute toxicity of total flavonoids from Radix Scutellariae and its effect on experimental arrhythmia induced by aconitine in rats. Methods: ① The acute toxicity of total flavonoids of Scutellaria baicalensis Georgi was determined by Bliss method; ② The anti-arrhythmic effect of Scutellaria baicalensis total flavone was studied by measuring the electrocardiogram in rats. Results: ① The total flavonoids of Radix Scutellariae had some acute toxicity to mice, but the median lethal dose (20mg · kg-1 body weight) and the median lethal dose (LD50, 4.4388g · kg-1 body weight) (2) The total flavonoids of Radix Scutellariae could significantly increase the threshold dose of aconitine-induced ventricular premature ventricular (VP), ventricular fibrillation (VF) and ventricular arrest (CA) in a dose-dependent manner To shorten the duration of epinephrine-induced guinea pig arrhythmia. Conclusion: The total flavonoids from Scutellaria baicalensis Georgi are less toxic to mice but have obvious anti-experimental arrhythmia effects.