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为研究宫腔液中的生化组份对含铜宫内节育器 (Cu IUD)中铜离子释放行为的影响 ,在体外模拟试验条件下考察了人血液中的三种蛋白质 (白蛋白、丙球蛋白、血红蛋白 )对铜腐蚀行为的影响。极化电阻测试的结果表明 ,有蛋白质存在时总是使铜的腐蚀速度增大 ,但不同蛋白质的影响规律不同。白蛋白的浓度较小 (<1 g/ L)时 ,铜的腐蚀速度随白蛋白浓度的增大而增大 ;当白蛋白浓度较大 (>1 g/ L )时 ,增大浓度使铜的腐蚀速度反而有所减小并趋于一稳定值。而同样的测试表明 ,铜的腐蚀速度总是随丙球蛋白或血红蛋白浓度的增大而增大。这三种蛋白质都使铜在模拟宫腔液中的自腐蚀电位负移 ,说明蛋白质通过加速铜的阳极溶解过程而促进了铜在模拟宫腔液中的腐蚀。
In order to study the effect of biochemical components in uterine fluid on Cu IUD release in copper-containing IUDs, three proteins in human blood (albumin, Protein, hemoglobin) on copper corrosion behavior. The result of the polarization resistance test shows that in the presence of protein, the corrosion rate of copper is always increased, but the influence laws of different proteins are different. The corrosion rate of copper increased with the increase of albumin concentration when the albumin concentration was lower (<1 g / L). When the albumin concentration was higher (> 1 g / L), the concentration of copper The corrosion rate decreases but tends to a steady value. The same test shows that the corrosion rate of copper always increases with the concentration of globulin or hemoglobin. All three proteins negatively shift copper from the autocorrosion potential in simulated uterine fluid, indicating that protein promotes copper corrosion in simulated uterine fluid by accelerating the anodic dissolution of copper.