单磷酸类脂A(MPL)是类脂A 经酸控水解,失去1-磷酸后形成的一种类脂A衍生物。MPL 基本上失去了脂多糖(LPS)的毒性,但仍保留有一定的免疫调节作用:免疫佐剂和免疫调节作用、诱导机体产生各种免疫活性因子、激活吞噬细胞、诱导产生对LPS的早期耐受及增强机体抗病毒、细菌、寄生虫感染和抗肿瘤的非特异性抵抗力,是一种很有发展前途的免疫调节剂。 Monophosphoryl lipid A (MPL) is a lipid A derivatives by acid-controlled hydrolysis, the formation of a loss of 1-phosphate lipid A derivatives. MPL basically loses the toxicity of lipopolysaccharide (LPS), but still retains a certain degree of immunomodulatory effects: immune adjuvants and immunomodulatory effects, inducing the body to produce a variety of immunocompetent factors, activating phagocytes, inducing the early LPS Tolerance and enhance the body’s antiviral, bacterial, parasitic infections and anti-tumor non-specific resistance, is a promising immunomodulator.