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目的分析枸橼酸咖啡治疗早产儿呼吸暂停的临床效果。方法选取2014年9月-2015年9月中山大学附一院东院儿科收治的68例早产儿呼吸暂停患儿为研究对象,按照治疗方式分为对照组和试验组,每组各34例。对照组予以氨茶碱治疗,试验组予以枸橼酸咖啡因治疗。比较两组总有效率、氧气使用时间、呼吸暂停消失时间、血气指标和并发症发生情况。结果试验组总有效率高于对照组,并发症发生率低于对照组,氧气使用时间、呼吸暂停消失时间优于对照组,差异均有统计学意义(均P<0.05)。治疗前,两组血气指标比较,差异无统计学意义(P>0.05);治疗后,两组血气指标均有改善,实验组改善更为明显,实验组PaO_2高于对照组,PaCO_2低于对照组,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因临床效果肯定,可使并发症受到抑制,改善血气指标。
Objective To analyze the clinical effect of citric acid in the treatment of apnea in premature infants. Methods From September 2014 to September 2015, 68 infants with apnea in the East Hospital of Sun Yat-sen University Affiliated Hospital were enrolled. The subjects were divided into control group and experimental group according to the way of treatment, 34 cases in each group. The control group was treated with aminophylline, and the experimental group was given citrate caffeine. The total effective rate, oxygen usage time, disappearance time of apnea, blood gas index and complication were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group, and the incidence of complications was lower than that of the control group. The oxygen use time and the disappearance time of apnea were better than those of the control group (all P <0.05). Before treatment, there was no significant difference in blood gas indexes between the two groups (P> 0.05). After treatment, the blood gas indexes of both groups were improved, and the improvement of the experimental group was more obvious. The PaO_2 of the experimental group was higher than that of the control group, Group, the difference was statistically significant (P <0.05). Conclusion The positive clinical effect of citrate caffeine, complications can be inhibited, improve blood gas indicators.