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探索细胞凋亡在心血管系统的意义,应用TUNEL法、透射电镜技术观察20例冠心病猝死者梗死区心肌细胞凋亡现象。冠心病组梗死区心肌细胞凋亡千分率(557.94±144.10％)明显高于正常对照组(34.30±20.68％),P<0.01,并有趋势表明,冠状动脉粥样硬化病变支数越多,梗死区心肌细胞凋亡越明显。电镜下见有的心肌细胞出现胞核体积缩小、染色质边聚、核膜完整的早期凋亡特征;有的则出现染色质更浓密、电子密度明显增加、结构模糊不清、核膜仍完整的中晚期凋亡细胞特征。细胞凋亡在冠心病心肌梗死是一种相当重要的现象。
Explore the significance of apoptosis in the cardiovascular system, the application of TUNEL method, transmission electron microscopy observation of 20 cases of sudden death of coronary heart disease in myocardial infarction infarction phenomenon. Coronary heart disease myocardial infarction myocardial infarction rate (557.94 ± 144.10%) was significantly higher than the normal control group (34.30 ± 20.68%), P <0.01, and the trend shows that the more the coronary atherosclerosis lesions count , Myocardial infarction more obvious myocardial apoptosis. Electron microscope, some of the cells appeared myocardial cell shrinkage, chromatin edge polyps, nuclear membrane integrity of the early apoptotic features; while others appear more dense chromatin, electron density increased significantly, the structure is unclear, the nuclear membrane is still intact The characteristics of middle and late apoptotic cells. Apoptosis in coronary heart disease is a very important phenomenon.