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早在1924年,J K Clarke首先从人类龋齿损害中分离出了变形链球菌,他当时描述“从50颗牙齿中有36颗分离出了变形链球菌,它能迅速产酸,在24小时内使培养基的pH值由7降至4.2。所有分离出的菌种均能发酵葡萄糖、乳糖、棉子糖、甘露醇、菊粉和柳醇(Salicin)而产酸,在血琼脂平皿中既不溶血也不使只变色。变链菌落紧密地附着于牙面的这一现象具有极大的重要性”。但在此后的30年间,Clarke的发现并未受到足够重视。直至1960年Fitzgerald和Keyes等由患龋的大鼠和田鼠中分离出的某些链球菌菌株分别在“对龋病
As early as 1924, JK Clarke first isolated Streptococcus mutans from human dental caries lesions. At the time, he described "36 Streptococcus mutans isolated from 36 of the 50 teeth and is capable of producing acid quickly and within 24 hours The pH of the medium was reduced from 7 to 4.2 All isolates were able to ferment glucose, lactose, raffinose, mannitol, inulin and Salicin to produce acid, neither in the blood agar plate Hemolysis does not make only discoloration. Streptococcal colon closely attached to the tooth surface of this phenomenon is of great importance. However, Clarke's findings were not taken seriously enough in the next 30 years. Some strains of Streptococcus isolated from caries-infected rats and voles until 1960, such as Fitzgerald and Keyes,