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结核病化疗,通过40多年临床试验,现已确定了结核病化疗的两条基本原则:第一,有效的治疗必须在开始就使用至少两种敏感药物;第二,结核病的治愈必须是连续治疗到痰菌阴转和症状改善。近年来,结核病化疗方案的建立,目标在于尽可能在短时期内达到消灭结核病灶中的结核菌。一、近代结核病化疗的理论基础如何达到制菌、杀菌和灭菌,并尽可能使病变组织修复,保持长久的临床治愈是近代结核病化疗的目的,其理论基础涉及到细菌和抗结核药物两个方面。 (一)细菌:注意两方面问题。其一是避免结核菌以突变的方式产生耐药菌株;其二是结核菌可因其缓慢或间歇生长持续存活在病灶内。解决了这两个问
Tuberculosis chemotherapy, through more than 40 years of clinical trials, has now identified two basic principles of tuberculosis chemotherapy: first, effective treatment must be initiated with at least two sensitive drugs; second, the cure for tuberculosis must be continuous to sputum Negative changes of the bacteria and symptoms. In recent years, the establishment of chemotherapy programs for tuberculosis has aimed to achieve the elimination of TB in tuberculosis as soon as possible. First, the theoretical basis of modern TB chemotherapy How to achieve bacteriocidal, bactericidal and sterilization, and as far as possible to repair the diseased tissue, to maintain long-term clinical cure is the purpose of modern TB chemotherapy, the theoretical basis of which involves two bacterial and anti-TB drugs aspect. (A) bacteria: pay attention to two issues. One is to prevent M. tuberculosis from producing drug-resistant strains by mutation; the other is that M. tuberculosis can continue to survive within the lesion due to its slow or intermittent growth. Solved these two questions