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目的探讨分析血管生成抑制剂YH-16和5-氟尿嘧啶(5-FU)联合应用对结直肠癌肝转移的抑制作用。方法构建好结直肠癌肝转移动物模型，将42只裸鼠，随机分为四组：分别为生理盐水组12只、YH-16组10只、5-Fu组10只、YH-16联合5-Fu组10只，给药14d后处死。观察四组裸鼠各分级肝脏转移灶数及脾脏肿瘤的大小。结果 YH-16联合5-Fu组脾脏肿瘤体积小于生理盐水组、YH-16组、5-Fu组，具有差异性，有统计学意义(<0.05)；YH-16组、5-Fu组、YH-16联合5-Fu组Ⅲ级肝脏转移灶数目低于生理盐水组，有统计学意义(<0.05)。YH-16联合5-Fu组Ⅱ、Ⅲ级肝脏转移灶低于YH-16组、5-Fu组，有统计学意义(<0.05)。结论血管生成抑制剂YH-16具有抑制结直肠癌转移作用，YH-16和5-FU具有协同抑制转移的作用，抑制效果比两者单独使用显著。“,”Objective To investigate the angiogenesis inhibitors YH-16 and 5-fluorouracil (5-FU)combined inhibition of colorectal cancer liver metastasis.Methods To build a good animal model of colorectal liver metastases to 42 nude mice,were randomly divided into 4 groups:normal saline group and 12,respectively,YH-16 10,5-Fu group 10,YH-16 joint 5-Fu group of 10,only for 14 days to be put to death.To observe the classification number of liver metastases and four groups of nude mice spleen tumor size.Results The YH-16 joint 5-Fu spleen tumor volume less than physiological saline group,YH-16,5-Fu group,has the difference was statistically significant ( <0.05);YH-16,5-Fu group,YH-16 joint number5-Fu groupⅢliver metastases is lower than the normal saline group,with statistical significance ( <0.05).YH-16 joint 5-Fu groupII,Ⅲliver metastases is lower than the YH-16,5-Fu group,with statistical significance ( <0.05).Conclusion Angiogenesis inhibitors can inhibit YH-16 colorectal cancer metastasis,YH-16 and 5-FU have the function of the synergistic inhibition transfer,significant inhibition effect than the single use.