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目的:探讨抗苗勒氏管激素(AMH)、瘦素与多囊卵巢综合征(PCOS)发生、发展的关系。方法:测定56例PCOS患者血清AMH、瘦素、性激素,并取30例月经周期正常妇女进行对照。结果:PCOS组血清AMH明显高于对照组,PCOS组中高睾酮组AMH明显高于非高睾酮组,差异有极显著性;PCOS组血清瘦素明显高于对照组;PCOS组中血清AMH水平与睾酮水平呈显著正相关(r=0.713,P=0.001);PCOS组中瘦素与空腹胰岛素(FINS)存在正相关(r=0.655,P=0.002);多元线性回归分析瘦素与AMH存在相关(r=0.809,P=0.015)。结论:AMH与瘦素可能参与PCOS发生、发展并与性激素合成失调有关,测定血清AMH、瘦素水平为诊断和研究PCOS提供了一个重要的突破点。
Objective: To investigate the relationship between anti-mullerian hormone (AMH), leptin and the occurrence and development of polycystic ovary syndrome (PCOS). Methods: The serum levels of AMH, leptin and sex hormones were determined in 56 patients with PCOS. Thirty normal women of menstrual cycle were enrolled in this study. Results: The AMH in PCOS group was significantly higher than that in control group. The AMH in PCOS group was significantly higher than that in non-HT group, the difference was significant. Serum leptin in PCOS group was significantly higher than that in control group. (R = 0.713, P = 0.001). There was a positive correlation between leptin and fasting insulin (FINS) in PCOS group (r = 0.655, P = 0.002). Multiple linear regression analysis showed that there was a correlation between leptin and AMH (r = 0.809, P = 0.015). Conclusions: AMH and leptin may be involved in the development of PCOS, which is associated with the imbalance of sex hormones. Determination of serum AMH and leptin levels provides an important breakthrough point for the diagnosis and study of PCOS.