论文部分内容阅读
磷脂酰肌醇 3 -激酶 (P13 - K)是多磷脂酰肌醇通路中一个重要的效应器和涉及信号转导、细胞转化的关键酶。P13 - K根据结构的相似性和底物的特殊性可分为 3种类型 ,其中第一种类型的 P13 - K是由 85 k D(p85 α和 p85 β)调节亚基和 110 k D(p110 α、p110 β和 p110 δ)催化亚
Phosphatidylinositol 3 - kinase (P13 - K) is an important effector in polyphosphatidylinositol pathway and a key enzyme involved in signal transduction and cell transformation. P13 - K can be divided into three types according to structural similarity and substrate specificity. The first type of P13 - K consists of 85 kD (p85 α and p85 β) regulatory subunits and 110 kD ( p110 α, p110 β, and p110 δ) catalytic subunit