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1948年Jacobson等报告,输入同种异体脾细胞或骨髓细胞,都可保护受到致死性全身放射照射的小白鼠免于死亡。进一步实验证明这种保护作用,系供体细胞在受体骨髓内增殖所致,从而为骨髓移植的临床应用奠定了实验基础。50年代Barnes及60年代Mathé等经动物实验及临床观察证实,用超致死量~(60)钴_(1000)拉德作全身照射(简称TBI),然后作骨髓移植,可治疗再生障碍性
In 1948, Jacobson et al. Reported that the input of allogeneic spleen cells or bone marrow cells can protect mice from lethal whole body radiation from death. Further experiments showed that this protective effect was caused by the proliferation of donor cells in the bone marrow of recipients, which laid the experimental foundation for the clinical application of bone marrow transplantation. Barnes in the 1950s and Mathé in 1960s and other animal experiments and clinical observations confirmed that with ultra-lethal dose of cobalt 60 (1000) Rad for whole body irradiation (TBI), and then for bone marrow transplantation, can treat aplastic