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目的探讨胃肠道肿瘤根治术后患者腹腔内的压力变化。方法随机选取2008年11月至2009年11月我院收治的胃肠道肿瘤患者96例,按照单双数原则将其分为两组,静脉化疗组患者采用静脉化疗,腹腔化疗组患者采用腹腔化疗,对比两组患者腹腔内压力变化和临床效果,并进行综合评价。结果静脉化疗组患者1年后、2年后、3年后的生存率分别为81.2%、66.7%、62.5%,腹腔化疗组患者1年后、2年后、3年后的生存率分别为95.8%、83.3%、79.2%,腹腔化疗组患者的治疗效果明显优于静脉化疗组,差异有统计学意义(P<0.05);3年后,静脉化疗组复发5例(10.4%),腹腔化疗组复发2例(4.2%),腹腔化疗组患者的复发率明显低于静脉化疗组,差异有统计学意义(P<0.05)。结论胃肠道肿瘤根治术后给予患者采用腹腔化疗,有利于改善病情,降低术后复发率,且疗效确切,安全可靠。
Objective To investigate the changes of intra-abdominal pressure in patients with gastrointestinal cancer after radical operation. Methods A total of 96 patients with gastrointestinal cancer who were admitted to our hospital from November 2008 to November 2009 were randomly divided into two groups according to the principle of single and double number. The patients in the intravenous chemotherapy group received intravenous chemotherapy. The patients in the abdominal chemotherapy group received intraperitoneal Chemotherapy, intraperitoneal pressure changes and clinical effects were compared between the two groups, and a comprehensive evaluation was made. Results After 1 year, 2 years and 3 years after operation, the survival rates of patients in IV chemotherapy group were 81.2%, 66.7% and 62.5% respectively. After 1 year, 2 years and 3 years, the survival rates of patients in IVC group were 95.8%, 83.3% and 79.2% respectively. The therapeutic effect of intraperitoneal chemotherapy group was superior to that of intravenous chemotherapy group (P <0.05). After 3 years, 5 cases (10.4% The recurrence rate was significantly lower in the chemotherapy group than in the chemotherapy group (2%, 4.2%). The difference was statistically significant (P <0.05). Conclusion Intraperitoneal chemotherapy is given to patients after radical operation of gastrointestinal tumors, which is beneficial to improve the condition and reduce the recurrence rate. The curative effect is exact, safe and reliable.