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目的探讨坦度螺酮联合帕罗西汀治疗脑卒中合并抑郁的临床疗效。方法选择2013年1月—2014年1月在千秋煤矿职工医院接受治疗的脑卒中合并抑郁患者170例,随机分成研究组和对照组,每组85例。对照组给予帕罗西汀治疗,研究组给予坦度螺酮联合帕罗西汀治疗,比较两组治疗前后的汉密尔顿抑郁量表(HAMD)评分、神经功能缺损程度量表(MESSS)评分,以及治疗后的副反应量表(TESS)评分和临床疗效。结果治疗前两组HAMD、MESSS评分比较,差异无统计学意义(P>0.05),治疗后研究组患者HAMD、MESSS评分低于对照组,差异有统计学意义(P<0.05);两组患者TESS评分比较,差异无统计学意义(P>0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。结论坦度螺酮联合帕罗西汀治疗脑卒中合并抑郁可以有效缓解患者焦虑抑郁状态,改善神经功能缺损,并提高治疗有效率。
Objective To investigate the clinical efficacy of tandospirone combined with paroxetine in the treatment of stroke complicated with depression. Methods A total of 170 patients with stroke complicated with depression who were treated in Qianqiu Coal Mine Workers Hospital from January 2013 to January 2014 were randomly divided into study group and control group with 85 cases in each group. The control group was treated with paroxetine. The study group was treated with tandospirone and paroxetine. The Hamilton Depression Rating Scale (HAMD), the MESSS score, and the post-treatment side score Response scale (TESS) score and clinical efficacy. Results There was no significant difference in HAMD and MESSS scores between the two groups before treatment (P> 0.05). After treatment, the scores of HAMD and MESSS in the study group were lower than those in the control group, with significant difference (P <0.05) TESS score, the difference was not statistically significant (P> 0.05). The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion Tandospirone combined with paroxetine in the treatment of stroke complicated with depression can effectively relieve anxiety and depression in patients, improve neurological deficits and improve the treatment efficiency.