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背景:青少年抑郁症对患者及其家庭成员会产生长期严重的痛苦,但这种致残状况的潜在机制仍不清楚。目的:比较未经药物的青少年首发抑郁症患者和匹配的对照者之间的大脑功能静息状态。方法 :使用3T磁共振扫描仪对15名青少年抑郁症患者和16名对照者进行功能磁共振静息状态扫描。采用低频振荡振幅(amplitude of low frequency fluctuation,ALFF)来评估脑功能静息态。结果 :青少年抑郁症患者的儿童抑郁量表评分的均值(标准差)高于对照组(22.13[9.21]与9.37[5.65])。与对照组相比,青少年抑郁症患者在扣带回后部、左颞下回、右颞上回、右岛叶、右侧顶叶和右侧梭状回具有较高的ALFF;而在双侧楔叶、左枕叶和左内侧额叶表现出较低的ALFF。结论 :青少年抑郁症与大脑多个区域的显著功能变化有关。
Background: Adolescent depression causes long-term and severe distress to patients and their family members, but the underlying mechanism of this disabling condition remains unclear. PURPOSE: To compare the resting state of brain function between untreated juvenile patients with first-episode depression and matched controls. METHODS: Fifteen adolescent depression patients and 16 controls were scanned for functional magnetic resonance rest state using a 3T magnetic resonance scanner. The amplitude of low frequency fluctuation (ALFF) was used to assess resting brain function. Results: The mean (standard deviation) of children’s depression scale in adolescent depression was higher than that of the control group (22.13 [9.21] vs 9.37 [5.65]). Compared with the control group, adolescent depression patients had higher ALFF in the cingulate gyrus, the left inferior temporal gyrus, the right superior temporal gyrus, the right island leaf, the right parietal lobe and the right fusiform gyrus; Side wedge leaves, left occipital lobe and left medial frontal lobe showed lower ALFF. Conclusions: Depression in adolescents is associated with significant functional changes in multiple regions of the brain.