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乙胺碘呋酮(Amiodarone,胺碘酮)系苯丙呋喃衍生物,为目前儿科较常用的广谱抗心律失常药。近年有关报告日渐增多,本文试从儿科临床应用的有关问题进行探讨。一、胺碘酮给药方案由于对胺碘酮的作用机制和药代动力学未完全清楚,因此儿科给药方案主要是经验性的。国外1980年Coumel等报告胺碘酮治疗小儿心律失常135例,剂量10～15 mg/(kg·d),4～14天后减至5 mg/(kg·d),每周服5天,总有效率93％,副作用率21.2％;1984年Garson等报告胺碘酮治疗儿童及青年心律失常39例,口服剂量2.5～15 mg/(kg·d),总有效率87.2％,副作用率
Amiodarone (Amiodarone) is a derivative of benzofuran, a common broad-spectrum antiarrhythmic drug currently used in pediatrics. In recent years, the reports are increasing day by day, this article tries to discuss the related problems of clinical application of pediatrics. First, the amiodarone drug regimen As the mechanism of amiodarone and pharmacokinetics is not fully understood, so the pediatric dosing regimen is mainly empirical. In 1980 Coumel et al reported that amiodarone treatment of 135 cases of children with arrhythmia, the dose of 10 ~ 15 mg / (kg · d), 4 to 14 days to 5 mg / (kg · d), 5 days a week, total The effective rate was 93% and the side effect rate was 21.2%. In 1984, Garson et al reported that 39 cases of amiodarone were treated with amiodarone at an oral dose of 2.5-15 mg / (kg · d) and the total effective rate was 87.2%