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普鲁卡因(奴佛卡因盐基)油注射液自1952年始厂泛用于临床,作为持久性麻醉剂和镇痛剂,常用浓度为2—10%,止痛有效时间据报导为4—20天。该注射液制造要点之一是由盐酸普鲁卡因加硷制得二水合普鲁卡因,后者脱水后即得无水普鲁卡因。无水普鲁卡因溶于注射用油中,经灭菌制剂的操作步骤就可制得普鲁卡因油注射液。制造过程一般采用本刊1953年6期224页所介绍的方法。
Prochlorocaine (Novocaine-based) oil injection has been used clinically since 1952 as a sustained-release anesthetic and analgesic at a common concentration of 2 to 10% with an analgesic effective time of 4-20 day. One of the key points of the injection is that procaine dihydrate is made from procaine hydrochloride and the latter is dehydrated to obtain anhydrous procaine. Anhydrous procaine is dissolved in the oil for injection, procaine oil injection can be prepared by the steps of the sterilization preparation. The manufacturing process generally used in this issue of 1953 6 224 pages of the method described.