由于放置压力平衡管或典型的慢性化脓性中耳炎所导致的鼓膜穿孔,通常需行鼓室成形术以期闭合。由于手术费用高、风险大,人们开始寻求费用低的非手术疗法,其中生长加速因子的应用是最有希望的方法。采用6周龄雌、雄有色豚鼠,造成单耳鼓膜穿孔动物模型,受试耳每周于鼓膜上直接应 Tympanoplasty is usually performed in order to close due to tympanic membrane perforation caused by placement of a pressure equalization tube or a typical chronic suppurative otitis media. Due to the high cost and high risk of surgery, people began to search for low-cost non-surgical therapy. Among them, the application of growth-accelerating factor is the most promising method. Using 6-week-old female and male guinea pigs, resulting in a single eardrum perforation animal model, the test ear on the tympanic membrane weekly should be