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遗传因素是心脏传导阻滞的发生机制之一。遗传性房室阻滞 (AVB)常呈常染色体显性遗传。钠离子通道编码基因SCN5A突变可以引起进行性和非进行性AVB ;同源框转录因子编码基因NKX2 5在心脏发生和房室结发育及人的一生中维持房室结的功能起着重要的调节作用。先天性AVB可能与内源性反转录病毒 3膜蛋白表达有关。
Genetic factors is one of the mechanisms of heart block. Hereditary atrioventricular block (AVB) often autosomal dominant. The SCN5A mutation in the sodium ion channel gene can cause both progressive and non-progressive AVB. The function of the homeobox transcription factor encoding gene NKX2 5 to maintain atrioventricular nodal function during cardiogenesis and atrioventricular node development and in human life plays an important role effect. Congenital AVB may be related to endogenous retrovirus 3 membrane protein expression.