病原体、肿瘤细胞在与宿主的相互作用中 ,为求生存可建立一系列免疫逃避机制以抵抗机体免疫系统的攻击。其中对MHC- I类分子限制性抗原呈递途径进行干扰则被认为是内源性抗原 (肿瘤抗原、病毒抗原等 )逃避免疫识别免遭清除的主要机制之一。该机制中 ,针对抗原加工转运蛋白 (TAP Pathogens, tumor cells in the interaction with the host, in order to survive to establish a series of immune evasion mechanisms to resist the body’s immune system attacks. Among them, the interference of MHC class I restricted antigen presenting pathways is considered as one of the major mechanisms that evade immune recognition from endogenous antigens (tumor antigens, viral antigens, etc.). In this mechanism, targeting antigen processing transporter (TAP