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对46例冠心病患者及32例年龄相近的正常人的血桨血栓素B_2(TXB_ 2)、6—酮—前列腺素F_(1α)(6—keto—PGF_(1(?))的含量及两者比值与冠状动脉造影结果进行了对比研究。结果表明:(1)冠心病患者血桨TXB_2含量增高,6—keto—PGF_(1α)含量下降,两者比值明显升高;(2)冠脉造影正常的冠心病患者与冠脉造影正常的正常对照者相比,TXB_2水平、TXB_2/6—keto—PGF_(1α)比值增高,而6—keto—PGF_(1α)水平下降;(3)血浆6—keto—PGF_(1α)含量随着冠状动脉病变严重程度的增加而降低。
Thromboxane B 2 (TXB2) and 6-keto-prostaglandin F (1α) (6-keto-PGF_ (1)) in 46 patients with coronary heart disease and 32 normal subjects The results showed that: (1) The content of TXB2 in blood of CHD patients increased and the content of 6-keto-PGF_ (1α) decreased, the ratio between the two was significantly higher; (2) Compared with normal coronary angiography, patients with normal coronary angiography had higher levels of TXB_2 and higher TXB_2 / 6-keto-PGF_ (1α), while their levels of 6-keto-PGF_ (1α) Plasma 6-keto-PGF_ (1α) levels decreased with the severity of coronary lesions.