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巨噬细胞活化综合征是一种多见于儿童慢性风湿性疾病的严重、致命性并发症,其发病机制尚不完全清楚,目前仍没有统一的诊断标准,早期诊断有一定难度。文章综述了近几年巨噬细胞活化综合征发病机制的研究新进展以及早期诊断的生物学标志物。[临床儿科杂志,2012,30(5):496-498]
Macrophage activation syndrome is a serious and fatal complication which is more common in children with chronic rheumatic diseases. The pathogenesis of macrophage activating syndrome is not yet fully understood. There is still no unified diagnostic criteria and there are some difficulties in early diagnosis. In this review, we review recent advances in the pathogenesis of macrophage activating syndrome and biomarkers for early diagnosis. [Journal of Clinical Pediatrics, 2012,30 (5): 496-498]