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目的探讨T2DM患者血清非磷酸化-未羧化的基质gla蛋白(dp-ucMGP)水平与膝下动脉钙化的关系。方法收集2014年5月至2015年5月于我院内分泌科或血管外科住院的146例T2DM患者,ELISA检测血清dp-ucMGP水平。所有研究对象均行下肢动脉64排螺旋CT血管成像(CTA)并计算膝下动脉钙化积分,检测患者HbA_1c、血钙、血磷、甲状旁腺激素(PTH),25羟维生素D[25(OH)D]水平。结果根据膝下动脉钙化积分分为:正常组(NC,n=20)、轻中度钙化组(n=70)和重度钙化组(n=56),各组血清dp-ucMGP水平分别为330(265.5,394.5)、480(407,553)、720(640,800)pmol/L(P<0.01);与NC组比较,轻中度钙化组和重度钙化组男性、年龄、心血管疾病病史、BMI、WHR、血清PTH水平差异均有统计学意义(P<0.05或P<0.01)。多因素回归分析发现,血清dp-ucMGP水平是膝下动脉钙化的独立预测因素,独立于年龄、性别、心血管疾病病史。结论血清高水平dp-ucMGP与T2DM患者膝下动脉钙化积分独立相关。
Objective To investigate the relationship between serum non-phosphorylated and non-carboxylated matrix protein (dp-ucMGP) and arterial calcification in T2DM patients. Methods A total of 146 T2DM patients hospitalized in Department of Endocrinology or Vascular Surgery from May 2014 to May 2015 were collected for ELISA. Serum levels of dp-ucMGP were detected by ELISA. All patients underwent 64-slice spiral CT angiography (CTA) of lower extremity arteries and calcification score of knee artery were calculated. HbA1c, serum calcium, phosphorus, PTH, 25 (OH) D] level. The results were divided into normal group (NC, n = 20), mild to moderate calcification group (n = 70) and severe calcification group (n = 56) according to calcification score of knee artery. The levels of dp-ucMGP in each group were 330 (P <0.01). Compared with NC group, the difference of male, age, history of cardiovascular disease, BMI, WHR, Serum PTH levels were significantly different (P <0.05 or P <0.01). Multivariate regression analysis found that serum dp-ucMGP level was an independent predictor of knee artery calcification independent of age, gender and cardiovascular disease history. Conclusion Serum high level of dp-ucMGP is independently associated with calcification score of inferior arteries in patients with T2DM.