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本文进一步研究了茶黄烷醇类(TF)对血小板聚集以及人血小板丰富血浆产生TXA_2的影响.实验结果表明,TF不但显著地抑制ADP、肾上腺素(Adr),花生四烯酸(AA)诱导的血小板聚集,还明显地抑制了血小板聚集曲线的幅度.高浓度TF对ADP诱导的血小板聚集的抑制程度大于低浓度TF;与阿斯匹林相似,TF不能对已发生聚集的血小板起解聚作用;TF还能明显地抑制人血小板丰富血浆产生血栓素B_2(TXB_2).12名陈旧性心肌梗塞患者经服用粗制的TF2个月后,血小板聚集性及TXB_2水平显著下降.
This study further investigated the effect of TF on platelet aggregation and platelet-rich plasma production of TXA2.Experimental results show that TF not only significantly inhibits the induction of ADP, adrenaline and arachidonic acid (AA) Platelet aggregation also significantly inhibited the amplitude of platelet aggregation.High concentration of TF ADP-induced platelet aggregation inhibition is greater than the low concentration of TF; similar to aspirin, TF can not have been gathering on the aggregation of platelets TF also significantly inhibited the production of thromboxane B 2 (TXB 2) in human platelet-rich plasma.Plasma aggregation and TXB 2 levels were significantly decreased in 12 elderly patients with myocardial infarction after taking TF for 2 months.