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本工作选择牛磺胆酸钠作为人体内胆汁酸盐的代表研究其对胆色素结石的重要成分——胆红素钙沉淀过程的影响。结果表明,牛磺胆酸钠的存在使胆红素钙沉淀的条件溶度积大大提高,并使沉淀反应速度大大减慢。在牛磺胆酸钠浓度较高的情况下,沉淀过程出现诱导期,说明牛磺胆酸钠在一定条件下可以抑制胆红素钙沉淀的形成。沉淀的红外光谱表明,牛磺胆酸并未结合在沉淀中,也未影响沉淀中胆红素与钙离子间的相互作用的部位。沉淀的扫描电镜观察结果经统计学处理表明牛磺胆酸钠的存在使沉淀的颗粒变小,颗粒的聚集程度减小。
This work chooses sodium taurocholate as a representative of bile salts in human body to study its influence on the process of bilirubin calcium precipitation, which is an important component of biliary pigment stone. The results showed that the presence of sodium taurocholate bilirubin precipitated calcium conditions greatly increased the solubility product, and greatly slow down the precipitation reaction. In the case of high concentration of sodium taurocholate, the induction period of precipitation appeared, indicating that under certain conditions, sodium taurocholate can inhibit the formation of calcium bilirubin precipitation. Infrared spectra of the precipitate showed that taurocholic acid did not bind in the precipitate nor did it affect the site of the interaction between the bilirubin and the calcium ion in the precipitate. The results of SEM observation showed that the existence of sodium taurocholate reduced the size of the precipitated particles and decreased the aggregation degree of the particles.