Objective: To analyze the medication rule of Traditional Chinese Medicine (TMC) in treating acute ischemic stroke (AIS) with phlegm-heat syndrome based on date mining. Methods: All clinical studies of TMC treatment for phlegm heatexcess pattern stroke at acute stage were searched from SinoMed, CNKI, VIP, Wanfang, Pubmed. The retrieval time was from the establishment of each database to 27 April 2020. Establish database through “Ancient and Modern Medical record Cloud platform (V2.2.3)” software. SPSS20.0 and SPSS Modeler 18.0 software was used to explore clustering analysis and drug association rule analysis of high frequency drugs. Results: 60 articles were finally included and 59 prescriptions were collected. The result shows that the commonly used drugs are mostly warm and cold, and the taste is mainly sweet and bitter. The main distribution of meridian tropism is stomach, liver and spleen. In these prescriptions, the frequently used drug pairs were “Trichosanthis fructus”, “Rhei radix et rhizoma” and so on. The association analysis results showed that “Arisaema cum bile-Rhei radix et rhizoma” had the highest correlation. The clustering analysis figured out 2 groups of the herbs. Conlusion: The TCM treatment of AIS should be based on the drugs of clearing heat, resolving phlegm and dredging viscera. Because most of these drugs are bitter and cold, we should pay attention to taking care of the spleen and stomach while expelling evil.