本文对10例急性脑膜炎球菌败血症病人皮肤出血斑活体标本,通过光学,免疫萤光和电子显微镜观察,试图解释皮肤损害的病理机制。光学显微镜下可见:皮肤损害处广泛的血管损伤,真皮小血管和毛细血管的内皮肿胀、坏死及出血,嗜中性白细胞浸润,在嗜中性白细胞胞浆内,内皮细胞及损伤血管外 In this paper, 10 cases of acute meningococcal sepsis in patients with bleeding plaque specimens, by optical, immunofluorescence and electron microscopy, trying to explain the pathological mechanism of skin lesions. Light microscopy shows: extensive damage to the skin at the vascular injury, dermal small capillaries and endothelial swelling, necrosis and bleeding, neutrophil infiltration, neutrophil cytoplasm, endothelial cells and vascular injury