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目的探讨甘氨酸螯合亚铁治疗妊娠期缺铁性贫血的疗效及不良反应。方法采用多中心、前瞻性、病例对照的方法,202例缺铁性贫血的孕妇按门诊就诊号分为实验组(107例)和对照组(95例)。实验组给予甘氨酸螯合亚铁治疗,对照组给予多糖铁复合物治疗。治疗3个月,观察治疗前后患者的红细胞计数(RBC)、血红蛋白(Hb)、血清铁蛋白(SF)水平及不良反应的发生率。结果治疗3个月后,实验组的RBC(3.98±0.44)高于对照组(3.72±0.55),P=0.025;实验组的Hb(117.33±9.17)高于对照组(111.56±10.88),P=0.011;实验组SF为36.17,高于对照组的25.25,P=0.030。实验组出现1例胃肠道反应,对照组出现2例便秘,两组的不良反应比较无统计学意义。结论甘氨酸螯合亚铁可以治疗妊娠期缺铁性贫血,较多糖铁复合物更有效,并且未见增加不良反应率。
Objective To investigate the efficacy and side effects of glycine chelate ferrous iron in the treatment of iron deficiency anemia during pregnancy. Methods A total of 202 pregnant women with iron deficiency anemia were divided into experimental group (n = 107) and control group (n = 95) according to outpatient visit by multi-center, prospective and case-control method. The experimental group was treated with chelating ferrous glycinate and the control group with polysaccharide-iron complex. The patients were treated for 3 months. The RBC, Hb, SF and the incidence of adverse reactions were observed before and after treatment. Results After 3 months of treatment, the RBC in the experimental group was significantly higher than that in the control group (3.72 ± 0.55, P = 0.025); the Hb (117.33 ± 9.17) in the experimental group was significantly higher than that in the control group (111.56 ± 10.88) = 0.011; SF in experimental group was 36.17, which was higher than 25.25 in control group, P = 0.030. One case of gastrointestinal reaction occurred in the experimental group and two cases of constipation in the control group. There was no significant difference in adverse reactions between the two groups. Conclusion Glycine chelate ferrous iron can be used to treat iron deficiency anemia during pregnancy, more iron and iron complexes more effective, and no increase in adverse reaction rates.