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目的 探讨老年Ｇｒａｖｅｓ 病骨病的发病机制，对不同治疗阶段患者血清骨钙素（ＢＧＰ）及甲状腺功能进行检测并作对比分析。方法 采用放射免疫技术检测Ｇｒａｖｅｓ 病患者血清ＢＧＰ及甲状腺功能指标（ＦＴ３ 、ＦＴ４ 、ＴＳＨ、ＴＧ－ Ａｂ、ＴＭ－ Ａｂ）。结果 Ｇｒａｖｅｓ 病患者血清ＢＧＰ明显升高，相关分析揭示ＢＧＰ与ＦＴ３ 、ＦＴ４ 呈正相关（ＦＴ３ ：ｒ＝ ０．５８２ ，Ｐ ＜ ０．０１；ＦＴ４ ：ｒ＝ ０ ．６２１，Ｐ＜ ０．０１），与ＴＳＨ、ＴＧ－ Ａｂ、ＴＭ－ Ａｂ 无相关（ Ｐ ＞ ０．０５） 。结论 ＢＧＰ 是Ｇｒａｖｅｓ 骨病病情控制与否的一项较敏感性指标，Ｇｒａｖｅｓ 病骨转换受ＦＴ３ 、ＦＴ４ 影响，而与机体免疫状态无相关。提示老年Ｇｒａｖｅｓ 病的防治主要是以抗甲亢治疗为基础Ｔ３ 、Ｔ４ 恢复至正常水平后才能使骨转换率尽快得到控制。
Objective To investigate the pathogenesis of osteoporosis in elderly patients with Graves’ disease and to detect and compare the serum BGP and thyroid function in patients with different stages of treatment. Methods Serum BGP and thyroid function indexes (FT3, FT4, TSH, TG-Ab and TM-Ab) were detected by radioimmunoassay in patients with Graves disease. Results Serum BGP was significantly increased in patients with Graves disease. Correlation analysis revealed that BGP was positively correlated with FT3 and FT4 (FT3: r = 0.582, P <0.01; FT4: r = No correlation with TSH, TG-Ab, TM-Ab (P> 0.05). Conclusion BGP is a more sensitive indicator of Graves ’disease control. Graves’ disease is affected by FT3 and FT4, but not related to immune status. Tip Prevention and treatment of elderly Graves disease is mainly based on anti-hyperthyroidism treatment T3, T4 returned to normal before the bone turnover rate can be controlled as soon as possible.