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应用肾上腺皮质激素治疗肾病综合征已有30余年历史。然而对激素的作用原理学者们的看法至今仍未趋于一致。目前公认激素除有推迟纤维化作用外,大剂量激素可扩张血管,增加肾小球滤过率,有利尿消肿作用。另有抑制抗利尿激素分泌,增加肾小球系膜的活性,有利于肾小球炎症的吸收,降低肾小球滤过膜的通透性。使用激素不是免疫抑制而是抗炎,理由是:①肾病综合征是免疫不足而不是促进,免疫不足用来抑制是不适合的。②过去认为影响免疫的看法来自动
Application of adrenal cortex hormones in the treatment of nephrotic syndrome has more than 30 years of history. However, the theory of action of hormones scholars still do not agree. The hormone is generally recognized in addition to delay the role of fibrosis, high-dose hormones can dilate blood vessels, increased glomerular filtration rate, diuretic swelling. Another inhibition of antidiuretic hormone secretion, increased mesangial activity, is conducive to the absorption of glomerular inflammation, reduce glomerular filtration membrane permeability. The use of hormones is not immunosuppressive but anti-inflammatory, the reasons are: ① nephrotic syndrome is not immune deficiency, and inadequate immunization to suppress is not suitable. ② In the past that the impact of immune opinion is automatic