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目的探讨异丙酚(丙泊酚)及异丙酚配伍安定静脉麻醉在早孕人工流产手术中的效果。方法选取自愿要求在镇静麻醉下进行人工流产手术的健康女性200例,随机分为两组,每组100例,对照组单用异丙酚1 mg/kg静脉推注,观察组芬太尼0.02 mg/kg静脉推注后异丙酚1 mg/kg静脉推注,监测用药前、用药后平均动脉压(MAP)、心率(HR)、外周血氧饱和度(SPO2);记录异丙酚的首次剂量和总剂量、用药后意识消失时间、苏醒时间以及用药后的不良反应。结果与手术前比较,MAP:对照组下降明显,与观察组比较,差异有统计学意义,P<0.05。HR:对照组与观察组均有下降,两组比较差异无统计学意义,P>0.05。SpO2:对照组下降明显,与观察组比较,差异有统计学意义,P<0.05。异丙酚的首次剂量和总剂量:观察组低于对照组,两组比较差异有统计学意义,P<0.05。用药后意识消失时间:观察组快于对照组,两组比较差异有统计学意义,P<0.05。用药后苏醒时间,两组间比较差异无统计学意义,P>0.05。用药后的不良反应:两组均未出现。结论异丙酚配伍芬太尼是一种可靠、安全、有效的用于人工流产的静脉麻醉方式。
Objective To investigate the effect of Propofol (Propofol) and Propofol combined with Anesthesia on abortion in early pregnancy. Methods A total of 200 healthy women who were asked to undergo artificial abortion under the sedation anesthesia were randomly divided into two groups (n = 100 in each group). The control group was given propofol 1 mg / kg intravenously only. The fentanyl 0.02 mg / kg propofol 1 mg / kg intravenously after bolus injection, mean arterial pressure (MAP), heart rate (HR) and peripheral blood oxygen saturation (SPO2) were monitored before and after treatment. Propofol The first dose and total dose, consciousness disappear after treatment time, recovery time and adverse reactions after treatment. Results Compared with those before surgery, MAP decreased significantly in the control group, with statistical significance (P <0.05). HR: The control group and the observation group have decreased, no significant difference between the two groups, P> 0.05. SpO2: The control group decreased significantly compared with the observation group, the difference was statistically significant, P <0.05. The first dose of propofol and total dose: the observation group was lower than the control group, the difference between the two groups was statistically significant, P <0.05. Consciousness disappeared after treatment: the observation group was faster than the control group, the difference between the two groups was statistically significant, P <0.05. Recovery time after treatment, no significant difference between the two groups, P> 0.05. Adverse reactions after treatment: Neither group appeared. Conclusion Propofol with fentanyl is a reliable, safe and effective method for intravenous anesthesia for induced abortion.