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用放射免疫法动态观察40例肺心病患者全血SOD-1的含量变化,并与健康参照组对比分析,结果表明:肺心病急性发作期全血SOD-1含量急剧升高,显著超过参照组(P<0.01);缓解期下降,显著低于参照组(P<0.01)。缺氧程度也显著影响全血SOD-1含量,急性发作期缺氧严重组升高程度远不及轻度和中度缺氧组。凡急性发作期全血SOD-1上升幅度低者预后均不良。
The content of SOD-1 in the whole blood of 40 patients with cor pulmonale was dynamically observed by radioimmunoassay and compared with the healthy reference group. The results showed that the content of SOD-1 in acute exacerbation of pulmonary heart disease increased sharply, which was significantly higher than that of the reference group (P <0.01). The remission period was significantly lower than that of the reference group (P <0.01). The level of hypoxia also significantly affected the level of SOD-1 in whole blood. The acute hypoxia in acute exacerbation was much less than that in mild hypoxia and moderate hypoxia groups. All acute exacerbation of whole blood SOD-1 increased rate of low prognosis are poor.