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目的：探讨阿立哌唑治疗精神分裂症血药阈浓度的范围。方法对78例服用阿立哌唑治疗的精神分裂症患者服药前后血药浓度进行监测，并与 PANSS量表评定结果进行相关性分析。结果阿立哌唑血药浓度与临床疗效有关，与年龄，性别无关；确立了有效血药阈浓度为123．23 ng‐378．50 ng · ml－1。结论阿立哌唑血药浓度达123．23 ng‐378．50 ng · ml－1之间时为最佳阈值范围，血药浓度与药物剂量、疗效呈正相关。药物剂量增加，起效加快，但不良反应亦随之增加。“,”Objective To explore the range of blood drug threshold concentration of aripiprazole in the treatment of schizophrenia .Methods Pre‐ and post‐medication blood drug levels were detected in 78 schizophrenics on aripiprazole and their correlation to the PASS results analyzed .Re‐sults Aripiprazole blood drug concentration was related to clinical efficacy and wasn ’t to ages and gen‐ders ;(123 .23‐378 .50) ng/ml was established as effective blood drug threshold concentration .Conclusi on Aripiprazole optimal threshold concentration is (123 .23‐378 .50) ng/ml and blood drug levels are posi‐tively related to dosage and efficacy .Aripiprazole takes effect more rapidly along with dosage increasing , but its adverse reactions increase .