【摘 要】
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Muscle atrophy is one of the most common and destructive events in chronic diseases.It is characterized by a decrease in the cross-sectional area of muscle fiber,myonuclear number,protein content,and muscle strength and an increase in fatigability.Muscle
【机 构】
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Institute of Pharmacy and Pharmacology,Hunan Provincial Key Laboratory of Tumor Microenvironment Res
论文部分内容阅读
Muscle atrophy is one of the most common and destructive events in chronic diseases.It is characterized by a decrease in the cross-sectional area of muscle fiber,myonuclear number,protein content,and muscle strength and an increase in fatigability.Muscle atrophy not only causes a decline in the quality of life of patients,but also poses a burden on society[1].The occurrence of muscle atrophy is related to many factors.From a macro point of view,there are age and disuse.At the micro level,the rate of protein degradation exceeds the rate of protein synthesis[2,3].To date,a plethora of therapeutic strategies in the treatment of muscle atrophy has been successfully developed,such as nutritional interventions,physical exercise,and electroacupuncture therapy,all of which can prevent and rescue muscle atrophy[4].However,there is no effective drug to treat muscle atrophy.Therefore,it is very necessary to better under-stand the fine-tuning network for the occurrence and development of muscle atrophy and it is also helpful to provide new strategies for the treatment and prevention of muscle atrophy in the future.
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