慢性肾脏病和终末期肾病患者常需补铁治疗。但近年来铁剂的使用逐年增加,带来了铁超载、氧化应激和超敏反应等新问题,并可能促进感染的发生,其使用的安全性受到关注。为此,改善全球肾脏病预后组织(KDIGO)召开专家组会议,全面评估铁剂使用的利和弊,并且提供合理使用方案以减轻急性反应及其他毒副作用。 Patients with chronic kidney disease and end-stage renal disease often require iron supplementation. However, the use of iron has been increasing year by year, bringing about new problems such as iron overload, oxidative stress and hypersensitivity, and may promote the occurrence of infection, and the safety of its use has drawn attention. To this end, the Global Organization for the Advancement of the Kidney Disease (KDIGO) has held an expert group meeting to thoroughly evaluate the pros and cons of iron use and to provide rational use programs to reduce acute and other side effects.