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目的:观察I型血红素氧化酶(HO-1)基因启动子GT重复长短对冠状动脉支架置入术后再狭窄的影响。方法:187例行冠状动脉支架置入术者,6个月时随访再狭窄情况。PCR和DNA测序仪确定HO-1启动子GT重复次数。高敏法测术前及术后24h、48h血浆白介素-6(IL-6)和C反应蛋白(CRP)值。结果:各基因型间术后IL-6和CRP水平及再狭窄发生率无差异,携较短GT者术前血浆IL-6水平比非短GT序列携带者低约33．3％(P=0．0008)。结论:HO-1基因多态性不影响支架置入术后炎症介质水平及再狭窄,但可能影响动脉粥样硬化形成的炎症过程。
Objective: To observe the effect of repetitive length of GT promoter HO-1 gene on restenosis after coronary stent implantation. Methods: 187 patients undergoing coronary stenting were followed up for restenosis at 6 months. PCR and DNA sequencer to determine the number of HO-1 promoter GT repeats. The contents of interleukin-6 (IL-6) and C-reactive protein (CRP) before and 24 h and 48 h after operation were determined by high-sensitivity method. Results: There was no difference in the levels of IL-6 and CRP and the incidence of restenosis among all genotypes. The preoperative plasma IL-6 levels in patients with shorter GT were 33.3% lower than those in non-short GT carriers (P = 0.0008). Conclusion: HO-1 gene polymorphism does not affect the level of inflammatory mediators and restenosis after stent implantation, but may affect the inflammatory process of atherosclerosis.