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为比较沙县在甲型肝炎（甲肝）疫苗免疫前后甲肝的发病情况，对本站疫情定收集的1990～1997年报告的882例甲肝病例进行了分析。结果表明，疫苗免疫前甲肝发病率在63.36／10万～99.90／10万，免疫后为16.20／10万～21.87／10万，免疫前后平均发病率之比为422：1。按＜15岁、15～44岁和≥45岁分组，发病率下降最明显的是＜15岁，其次是15～44岁和≥45岁，依次下降了91.9％、70.1％和37.1％．工人、农民、学生（大、小、小学生）不同职业人群，以学生下降最明显，农民下降不明显，存在差别的原因可能是甲肝疫苗接种率的高低。甲肝疫苗接种的成本效益为1：953．
In order to compare the incidence of hepatitis A in Shaxian before and after the hepatitis A (A) vaccine immunization, 882 cases of hepatitis A reported from 1990 to 1997 collected from this epidemic were analyzed. The results showed that the incidence of hepatitis A before immunization was between 63.36 / 100000 and 99.90 / 100000, and it was between 16.20 / 100000 and 21.87 / 100000 after immunization. The average morbidity ratio before and after immunization was 422: 1. By 15-year-old, 15-44-year-old and ≥45-year-old group, the most significant decrease was <15 years old, followed by 15-44 years old and ≥45 years old, decreasing by 91.9%, 70.1% and 37.1% respectively. Workers, peasants, students (primary, primary and secondary school students) with different occupational groups, the most obvious drop in students, peasants decline is not obvious, the difference may be due to the level of hepatitis A vaccination rates. The cost-effectiveness of hepatitis A vaccination is 1: 953.