青蒿素类主要用于治疗疟疾,对矽肺、烧伤后增生性瘢痕也有防治作用[1,2],尚未见其抗肝纤维化的报道。本研究采用CCl4诱发大鼠肝纤维化模型,观察青蒿琥酯(Artesu nate)的作用。1材料与方法1.1动物及饲养Wistar大鼠,清洁级,♀♂各半,♂,体重(240～280)g;♀,(200～240)g。购自军科 Artemisinin is mainly used for the treatment of malaria, and it also has preventive and therapeutic effects on silicosis and hypertrophic scars after burns [1, 2], and its anti-hepatic fibrosis has not yet been reported. This study used CCl4 to induce hepatic fibrosis in rats and observed the effects of artesunate. 1Materials and methods 1.1 Animals and rearing Wistar rats, clean grade, quail and halves, wolfberry, body weight (240-280) g; wolfberry, (200-240) g. Purchased from the Military Department