论文部分内容阅读
用原子吸收分光光度法测定人体口服葡萄糖酸钙片后的血钙浓度,其体内过程符合一室模型。主要动力学参数为:k_a=2.874 h~(-1);k_e=2.396 h~(-1);T_(2ke)~1=0.291 h;T_(max)=1.175 h;C_(max)=8.995μg/ml;AUC=9.638mg/(L·h);V=0.135 L;CL=0.333 Lh~(-1);T_(lag)=0.768 h;初步认为缺钙患者的临床给药方案应为每次 Ca~(2+)3 mg/kg,每1.5 h一次。
The concentration of calcium in human body after oral administration of calcium gluconate tablets was determined by atomic absorption spectrophotometry. The in vivo process conformed to the one-compartment model. The main kinetic parameters are: k_a = 2.874 h -1; k_e = 2.396 h -1; T 2ke -1 1 0.291 h; T max = 1.175 h; C max = 8.995 μg / ml; AUC = 9.638mg / (L · h); V = 0.135 L; CL = 0.333 Lh -1; T lag = 0.768 h; Each Ca ~ (2+) 3 mg / kg, once every 1.5 h.