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目的观察左卡尼汀辅助治疗老年难治性心力衰竭患者的临床疗效。方法将87例老年难治性心力衰竭患者随机分为观察组43例和对照组44例。对照组予利尿、强心、扩血管等常规抗心力衰竭药物治疗,观察组在此基础上加用注射用左卡尼汀,观察2组临床疗效及用药前后的N末端脑钠肽前体(NT-pro BNP)水平变化。结果观察组总有效率为79.1%高于对照组的52.3%,差异有统计学意义(P<0.05)。用药后2组NT-pro BNP水平均较用药前明显降低(P<0.01),且观察组NT-pro BNP水平明显低于对照组(P<0.05)。结论常规抗心力衰竭治疗药物联合左卡尼汀可显著提高临床疗效。
Objective To observe the clinical efficacy of levocarnitine in the treatment of senile patients with refractory heart failure. Methods A total of 87 elderly patients with refractory heart failure were randomly divided into observation group (43 cases) and control group (44 cases). The control group was treated with conventional anti-heart failure drugs such as diuretic, cardiotonic and vasodilator. On the basis of this study, the observation group was given L-carnitine for injection. The clinical efficacy and N-terminal pro brain natriuretic peptide NT-pro BNP) levels. Results The total effective rate in observation group was 79.1% higher than that in control group (52.3%), the difference was statistically significant (P <0.05). The levels of NT-pro BNP in the two groups were significantly lower than those before treatment (P <0.01), and the level of NT-pro BNP in the observation group was significantly lower than that of the control group (P <0.05). Conclusion Conventional anti-heart failure treatment combined with levocarnitine can significantly improve the clinical efficacy.