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研究了壳聚糖(CS)-聚环氧乙烯(PEO)和聚乳酸(PLA)-CS载药电纺纤维的牛血清蛋白(BSA)释放行为.利用原子力显微镜(AFM)观察了纤维在模拟体液中的分解与溶胀行为.CS-PEO纤维在模拟体液中分解10h时BSA总释放量高达96%,1d后纤维结构基本分解完全,在缓冲液中浸泡120min后纤维直径由浸泡10min时的0.727μm增大到1.43μm,纤维表面发生明显分解.CS-PEO和PLA-CS纤维具有不同的药物释放机制,CS-PEO载药纤维的药物释放主要是纤维结构快速分解,BSA扩散作用相对较弱;而后者在溶液中没有明显分解,浸泡30d后纤维直径从浸泡1d时的1.9μm增至2.8μm,BSA释放量不到总量的50%,其药物释放机制可能主要依靠BSA的扩散.
The bovine serum albumin (BSA) release behavior of chitosan (CS) -polyethylene oxide (PEO) and polylactic acid (PLA) -CS drug-loaded electrospun fibers was studied. Atomic force microscopy (AFM) The total release of BSA was as high as 96% after 10h decomposition of CS-PEO fiber in simulated body fluid, and the fiber structure basically decomposed after 1d. The fiber diameter of soaking in buffer for 120min was 0.727 μm to 1.43μm, the surface of the fibers decomposed obviously.CS-PEO and PLA-CS fibers have different drug release mechanisms, the drug release of CS-PEO drug-loaded fibers is mainly the rapid decomposition of the fiber structure, the relatively weak diffusion of BSA , While the latter did not decompose obviously in solution. The diameter of fibers increased from 1.9μm to 1.9μm at 1 day after immersion, and the release of BSA was less than 50% of the total amount. The drug release mechanism may rely mainly on the diffusion of BSA.