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目的 探讨苯接触史急性再生障碍性贫血(AAA)患者的临床特点及意义。方法 对1989~2004年解放军169医院收治的39例有苯接触史的AAA患者,按疗效分为有效组、无效组,与7例原发性AAA作比较,分析骨髓造血多项指标,并调查可能引起AAA的过去史。结果 有效组患者的骨髓造血指标明显优于无效组及原发性,而无效组与原发组相似。部分苯接触史AAA病前用过氯霉素、解热镇痛药,有的病人患有肝炎。结论 有效组属于有苯接触史的AAA,无效组可能为原发性AAA有苯接触史及骨髓造血指标积分大于4分、对治疗有效,可作为苯中毒AAA的诊断依据。骨髓造血指标可判断此类患者的预后。
Objective To investigate the clinical features and clinical significance of benzene exposure in patients with acute aplastic anemia (AAA). Methods A total of 39 patients with AAA history of benzene exposure from 169 hospitals of PLA from 1989 to 2004 were divided into effective group and ineffective group according to the therapeutic effect and compared with 7 cases of primary AAA to analyze the multiple indexes of bone marrow hematopoiesis May cause AAA past history. Results In the effective group, the hematopoietic index of bone marrow was significantly better than that of ineffective group and primary group, while the invalid group was similar to the primary group. Some benzene exposure History AAA used chloramphenicol before, antipyretic analgesics, and some patients with hepatitis. Conclusions The effective group belongs to AAA with history of benzene exposure. The invalid group may have history of benzene contact with primary AAA and the score of bone marrow hematopoiesis is more than 4 points, which is effective for treatment and can be used as diagnosis basis of benzene poisoning AAA. Marrow hematopoiesis indicators can determine the prognosis of such patients.