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目的:探讨高特灵和国产盐酸特拉唑嗪(海南绿岛)在治疗良性前列腺增生症(BPH)的治疗效果。方法:将80例BPH患者随机分成2组(Ⅰ、Ⅱ组),Ⅰ组服用盐酸特拉唑嗪(海南绿岛),Ⅱ组服用高特灵,观察治疗前后I-PSS症状评分、生活质量QOL评估、前列腺体积、残余尿量、最大尿流率、血压(收缩压、舒张压)、药物不良反应等指标的变化情况。结果:两组治疗后残余尿量、最大尿流率、国际前列腺症状评分较治疗前均有改善,但两组间差异无统计学意义。两组均未出现因不良反应而退出试验的病例,且两组间不良反应的发生率差异无统计学意义。结论:高特灵和盐酸特拉唑嗪(海南绿岛)治疗良性前列腺增生症均安全有效。
Objective: To investigate the therapeutic effect of Gortolol and telazosin hydrochloride (Hainan Green Island) in the treatment of benign prostatic hyperplasia (BPH). Methods: Eighty BPH patients were randomly divided into two groups (group Ⅰ and group Ⅱ). Group Ⅰ was treated with terazosin hydrochloride (Hainan Green Island), group Ⅱ was taken with gortolol, and the I-PSS symptom score, quality of life QOL assessment, prostate volume, residual urine volume, maximum flow rate, blood pressure (systolic blood pressure, diastolic blood pressure), adverse drug reactions and other indicators of change. Results: After treatment, the residual urine volume, maximum uroflow rate and International Prostate Symptom Score improved compared with those before treatment, but there was no significant difference between the two groups. There were no cases of withdrawal from adverse reactions in both groups, and there was no significant difference in the incidence of adverse reactions between the two groups. CONCLUSION: Gautrin and terazosin hydrochloride (Hainan Green Island) are safe and effective in the treatment of benign prostatic hyperplasia.