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目前对帕金森病(PD)的研究多集中在运动症状,对非运动症状的诊断及治疗尚处于较低水平。非运动症状种类繁多,包括睡眠障碍、神经精神症状、自主神经系统症状、消化道症状、感觉障碍等。这些症状可与PD的运动症状并行,也可先于或者晚于运动症状;可随运动症状波动,也可与之无关。今后的PD研究应集中在阐明非运动症状的病理生理机制和探索治疗策略上。
At present, most studies on Parkinson’s disease (PD) focus on motor symptoms, and the diagnosis and treatment of non-motor symptoms are still at a low level. A wide range of non-motor symptoms, including sleep disorders, neuropsychiatric symptoms, autonomic nervous system symptoms, gastrointestinal symptoms, sensory disturbances. These symptoms may be in parallel with the motor symptoms of PD, may also be earlier or later than motor symptoms; may fluctuate with motor symptoms, may also have nothing to do with them. The future of PD research should focus on elucidating the pathophysiology of non-motor symptoms and explore treatment strategies.