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目的了解药品不良反应(ADR)发生的特点和规律,促进临床合理用药。方法对我院2003-2010年度收集上报的312例ADR报告,按患者性别、年龄、药品种类、给药途径、不良反应临床表现进行统计分析。结果 312例ADR报告中,0～12年所占比例较高(31.49%),静脉滴注是引起ADR的主要给药途径(82.13%)。抗微生物药物引发的ADR所占比例最高,有224例,占72.02%;其中,以喹诺酮类(42.48%)和头孢菌素类(29.54%)为主。ADR的临床表现以皮肤及附件系统损害为主(40.13%),其次是全身性损害和消化系统损害。新的严重的ADR有19例。结论应重视药品不良反应,加强ADR的监测和上报工作。
Objective To understand the characteristics and rules of adverse drug reaction (ADR) and to promote rational drug use in clinic. Methods A total of 312 ADR cases reported in our hospital during 2003-2010 were collected and analyzed according to their gender, age, drug type, route of administration and clinical manifestations of adverse reactions. Results Among the 312 ADR cases, 0-12 years had a high proportion (31.49%). Intravenous drip was the main route of ADR (82.13%). Antibiotics induced the highest proportion of ADR, 224 cases, accounting for 72.02%; among them, quinolones (42.48%) and cephalosporins (29.54%) based. The clinical manifestations of ADR were mainly skin and accessory system (40.13%), followed by systemic and digestive system damage. The new serious ADR in 19 cases. Conclusions Should pay attention to adverse drug reactions, strengthen the monitoring and reporting of ADR.