论文部分内容阅读
目的 :检测 2型糖尿病患者的肺通气和弥散功能 ,探讨肺脏是否为糖尿病慢性病变的靶器官。方法 :对 10 7名 2型糖尿病患者行肺通气及弥散功能检测 ,并与 6 1名年龄、性别匹配的健康者比较。糖尿病患者需行糖化血红蛋白 (HbA1c)、尿白蛋白排泄率 (AER)检测、眼底检查以及神经传导速度检查 ,以评价血糖控制水平以及糖尿病微血管病变状况。结果 :2型糖尿病组肺通气功能与正常对照组相比 ,无显著差异。 2型糖尿病组一氧化碳弥散量 (DLCO)及单位肺泡容积的一氧化碳弥散量 (DLCO/VA)较对照组明显降低 (P <0 0 5 )。DLCO、DLCO/VA与微血管病变积分呈负相关 (r分别为 - 0 2 91、 - 0 32 4 ,P <0 0 1)。此外 ,DLCO/VA还与年龄、病程呈负相关 (r分别为- 0 2 6 9、- 0 2 36 ,P <0 0 5 )。结论 :2型糖尿病患者虽然肺通气功能基本正常 ,但有弥散功能受损 ,提示肺脏可能也是糖尿病慢性病变的靶器官之一。
OBJECTIVE: To detect the pulmonary ventilation and diffuse function in patients with type 2 diabetes mellitus (T2DM) and to explore whether the lungs are the target organ of chronic diabetic diseases. Methods: A total of 10 7 patients with type 2 diabetes mellitus were tested for pulmonary ventilation and diffuse function, and were compared with 61 matched healthy and age-matched subjects. Patients with diabetes mellitus are required to have HbA1c, AER, fundus examination, and nerve conduction velocity tests to assess glycemic control and diabetic microangiopathy. Results: There was no significant difference in lung ventilation between T2DM group and normal control group. Compared with the control group, the DLCO and DLCO / VA of alveolar volume in type 2 diabetic patients were significantly decreased (P <0.05). DLCO and DLCO / VA were negatively correlated with microvessel density (r = -0.291, - 0324, P <0.01). In addition, DLCO / VA was negatively correlated with age and duration (r = -0.269, -0.236, P <0.05). CONCLUSION: Although pulmonary ventilation is basically normal in patients with type 2 diabetes mellitus, it has impaired diffuse function, suggesting that lung may also be one of the target organs for chronic diseases of diabetes.