新生儿发育缺陷的病因比较复杂,某些畸形给儿童健康损害极大,治疗也较困难,积极研究预防小儿发育缺陷,是人民卫生工作者的责任。1960年澳大利亚妇科学家维廉首先发现孕妇服用反应停(Thalidomi-de)能引起新生儿严重畸形(无肢)。1965年日本西村秀雄报道:反应停主要侵犯桡骨、胫骨而形成短肢畸形,在国外已发生数千例。1972年维廉又发现在妊娠早期服用丙咪嗪(Imipramine),可致新生儿无臂,引起世界医学界密切注意医源性所致的胎儿畸形。随着医药科学的发展,孕妇广泛用药和某些诊治措施,接触某些金属元素,化学毒物等等因素,损害胎儿的报道日益增多,值得我们注意防止。 The etiology of neonatal developmental defects is more complex, some deformities to the great health damage of children, treatment is more difficult, and actively study the prevention of pediatric developmental defects, is the responsibility of people’s health workers. In 1960, Australian gynecologist William Wilhelm first discovered that Thalidomi-de in pregnant women can cause serious deformities (limbs) in newborns. Japan Nishimura Hideki in 1965 reported: reaction stop mainly violations of the radius, tibia and the formation of short limb deformities, thousands of cases have occurred in foreign countries. Wilhelm also discovered in 1972 that taking Imipramine in early pregnancy could result in no arm in the newborn, causing the medical profession in the world to pay close attention to iatrogenic fetal abnormalities. With the development of medical science, pregnant women widely used drugs and some diagnosis and treatment measures, contact with certain metal elements, chemical poisons and so on, increasing reports of fetal damage, it is worth our attention to prevent.