长效磺胺药2—磺胺—3—甲氧基吡嗪(Sulfamethoxypyrazine),简称磺胺甲氧吡嗪(SMPZ),是近年来合成的新型磺胺药物。我省开封制药厂已大量投产。其抗菌作用良好,尤其是和抗菌增效剂—三甲氧苄胺嘧啶(TMP)联合使用,不仅抗菌作用倍增,且对耐氯喹的疟原虫亦有效。目前国内外已广泛应用子临床。文献报导 SMPZ 和 TMP 合用毒性甚小,但在大剂量或亚急性、慢性毒性实验中,可引起动物(大鼠、狗等)体重下降及白细胞、红细胞和血小板计数均显著下降。为了进一步 Sulfamethoxypyrazine, sulfamethoxazole (SMPZ), is a new sulfonamide drug synthesized in recent years. Kaifeng Pharmaceutical Factory in our province has been put into operation in large quantities. Its antibacterial effect is good, especially with antibacterial synergist - trimethoprim (TMP) in combination, not only double the antibacterial effect, but also against chloroquine-resistant Plasmodium is also effective. At home and abroad have been widely used sub-clinical. SMPZ and TMP reported in the literature combined with very little toxicity, but in large doses or subacute and chronic toxicity experiments, animals (rats, dogs, etc.) can cause weight loss and white blood cells, red blood cells and platelet count were significantly decreased. To further